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KMID : 0374920050260010101
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Inje Medical Journal
2005 Volume.26 No. 1 p.101 ~ p.106
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Azathioprine-associated Acute Pancreatitis in Behcets Disease
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Kim Ki-Hyang
Kim Ae-Ran
Kwon Min-Jung
Park Ji-Hun
Kim Dong-Kie
Kim Yoon-Jung
Lee Young-Tae
Park Bo-Min
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Abstract
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Although many drug are thought capable of initiating acute pancreatitis, following azathioprine administration represents the 5% incidence by far the highest recorded incidence to date.
We report a 35-year-old male who developed acute pancreatitis in the course of treatment with azathioprine for Behcet’s disease. He was admitted due to abdominal pain, diarrhea, and fever for 10 days. Serum amylase and lipase levels were 510U/L and 3702U/L respectively. The abdominal CT scan revealed diffuse enlargement of the pancreas. There was no history of alcohol use or gall bladder disease. We considered drugs, especially azathioprine, as the cause of acute pancreatitis. We diagnosed it as acute pancreatitis.
The patient was treated conservatively with hydration and analgesics. The symptom subsided within four days. Five days later, azathioprine was resumed. And the patient complained of abdominal pain. The elevated levels of serum amylase and lipase confirmed the recurrence of pancreatitis. His symptom subsided when azathioprine intake the stopped, and the serum amylase and lipase levels returned to normal level within five days.
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KEYWORD
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Acute Pancreatitis, Azathioprine
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